Progesterone Suppositories: Benefits and Side Effects

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By SheCares Editorial Team | Updated: Mar 28, 2020

Progesterone Suppositories: Benefits and Side Effects

Although often overlooked, progesterone suppositories are a viable option for treating a progesterone deficiency invoked by a variety of hormonal disorders. Continue reading to discover more about progesterone suppositories, such as what they do, how and when they are used, and where to purchase them.

What are Progesterone Suppositories?

What are progesterone suppositories

Progesterone suppositories are solid unit dosages intended for application into body orifices, namely the vagina or rectum. Once inserted, they release progesterone over a prolonged period of time, allowing the hormone to be absorbed at a slow and steady rate.

Vaginal progesterone suppositories. Vaginal suppositories are can be inserted with an applicator or the index finger, depending on the size. They are designed to dissolve in mucous membrane secretions.

Rectal progesterone suppositories. Rectal suppositories are inserted up to an inch within the sphincter. They are cone-shaped and designed to melt at body temperature.

What do Progesterone Suppositories Do?

Progesterone suppositories are used to treat many hormonal irregularities, such as luteal phase defect, luteal phase spotting, and PMS, among others.

Progesterone Suppositories Benefits

Overall, progesterone suppositories are praised for being tolerated better than pills and injections. They help relieve a variety of hormonal disorder symptoms, such as:

Benefits of progesterone suppositories

Vaginal progesterone suppositories are also commonly used by women undergoing infertility treatments to prepare the endometrium for implantation or prevent a threatened abortion.

How and When to Use Progesterone Suppositories

How Do I Take a Progesterone Suppository?

How and when to use progesterone suppositories

As aforementioned, progesterone suppositories may be inserted vaginally or rectally. Use them at evenly spaced intervals or as prescribed the same time each day. 

For vaginal suppositories, an applicator assists with insertion of the medication into the vagina, similar to a tampon. This is usually performed two to three times daily.1 To avoid drainage after insertion, insert the suppository lying down. For this reason, it is often put in right before bedtime or when resting.

For rectal suppositories, the insertion process is much the same as vaginal suppositories. However, it is normally performed with the index finger instead of an applicator. Buttocks should be clenched together for a few seconds after insertion to assure the suppository does not come out. 

When Do I Use a Progesterone Suppository?

For hormonal disorder treatment, progesterone suppositories are generally prescribed for only 6 to 12 days at a time. When used as part of a fertility treatment, women may continue use for up to 12 weeks into the pregnancy.

Progesterone Suppositories Side Effects

Possible side effects of progesterone suppositories

Some mild side effects of suppositories include nausea, breast tenderness, drowsiness, mood swings, vaginal discomfort, irritability, or headaches, among others.

For specific use, this progesterone treatment may be used during early pregnancy, but under the supervision of a doctor. Women who are breastfeeding should be wary as the progesterone from suppositories does pass into breast milk.

More severe side effects include yellowing eyes and skin, breast lumps, depression, swelling of the ankles or feet, blood clots, coughing up blood, fainting, trouble breathing, slurred speech, and more.

Where Do I Buy Progesterone Suppositories?

Progesterone suppositories can be obtained with a doctor's prescription or over the counter at pharmacies and major online retailers. Use of over-the-counter progesterone suppositories should be consulted with a doctor for proper dosing. Improper usage can evoke various side effects.

Key Takeaways

In sum, similar to other progesterone treatments, progesterone suppositories - either administered vaginally or rectally - are used to treat symptoms brought on by hormonal disorders. Depending on the reason for usage, progesterone suppositories can be used for as little as two weeks to as long as three consecutive months. Women should be monitored throughout the treatment period for varying side effects that may evolve. This form of progesterone medication is available through prescription or over the counter. 

Find out how to naturally increase progesterone levels and evade unwanted side effects with progesterone supplements, which include a selection of herbal options.