Safety and Side Effects of Progesterone Medications

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By SheCares Editorial Team | Updated: Dec 19, 2019

Safety and Side Effects of Progesterone Medications

Progesterone side effects are experienced when too much of the hormone is taken orally, applied topically, or inserted, thus saturating the glands. Continue reading to learn more about the safety and side effects of progesterone medications so that you can take a productive step toward optimal hormonal health

Progesterone Side Effects

Each of the progesterone medications has its specific list of side effects according to particular use. Also, it is essential to keep in mind that every woman will react differently to certain medications.

The extensive list of side effects of too much progesterone includes, but is not limited to, the following:

More Common:

Progesterone medications potential side effects

Less Common:

  • Clear or bloody discharge from the nipple
  • Lump in the breast or under the arm 
  • Ovarian cysts 
  • Numbness of extremities 
  • Stomach pain 
  • Unexplained shortness of breath 
  • Depression
  • Seizures 
  • Coughing up blood 
  • Slurred speech 
  • Confusion 
  • Swelling of ankles or feet 
  • Yellowing eyes and skin 
  • Blurred vision 
  • Blood clots 
  • Alopecia 
  • Stroke 
  • Gallbladder disease 
  • Heart disease 
  • Breast cancer

Safety of Progesterone Medications

Safety of progesterone medications

In general, progesterone medications are safe to use with proper instruction. However, certain restrictions may apply for those who are pregnant or breastfeeding or for those with a history of heart or liver disease; stroke; or breast cancer.

In all cases, it is recommended to pursue check-up appointments every three to six months to monitor treatment effectiveness and adjust dosages as necessary.1

Nevertheless, to completely avoid the possible side effects of too much progesterone from taking exogenous hormone medications, explore natural progesterone supplements, specifically herbal options.