Progesterone during the Menstrual Cycle

On a monthly basis, glands control hormone production to regulate the menstrual cycle. The menstrual cycle is a biofeedback system, meaning that each gland and structure is affected by the activity of others. One of the principal sex hormones intricately involved with the healthy functioning of this monthly process happens to be progesterone.

Continue reading to learn more about the role of progesterone in the menstrual cycle as well as how progesterone levels fluctuate throughout the cycle stages.

Progesterone Before Ovulation

The first half of the menstrual cycle is known as the follicular phase, or the proliferative phase. It begins with the first day of menses and lasts until ovulation, usually ranging from 10 to 16 days.

During most of the follicular phase, progesterone levels are low, and the small amount of progesterone produced is derived from the adrenal cortex, as it is converted from an endogenous steroid known as pregnenolone. At this time, the contribution of the ovaries to the blood plasma levels of progesterone is minor.

It is reported that the progesterone produced during the follicular phase is important for subsequent ovulation, but it is after ovulation that progesterone dominates.

Progesterone After Ovulation

The second half of the menstrual cycle is called the luteal phase, or the secretory phase. The duration of the luteal phase is relatively constant in all women, lasting around 14 days.

The luteal phase is characterized by a gradual rise in progesterone. This hormone level increase begins shortly after ovulation and lasts until the beginning of the following menstrual cycle.

Accordingly, the source of progesterone shifts towards the ovaries as the hormone is secreted by the corpus luteum, a temporary structure formed from the ruptured follicle.

Progesterone produced during this time serves to maintain the thickened lining of the uterus in preparation for the fertilized egg to implant itself. It also prohibits uterine muscle contractions that would cause the body to reject an egg.

If pregnancy occurs, progesterone levels will remain high as the corpus luteum continues production until the placenta takes over. If pregnancy does not occur, the structure will deteriorate, causing progesterone levels to drop until the initiation of the next menstrual cycle.

In general, complications that arise with respect to progesterone levels during the menstrual cycle could lead to a myriad of long-term health problems.

For instance, women who have polycystic ovarian syndrome (PCOS) or are going through the menopausal transition will often experience anovulatory cycles. Since an anovulatory cycle is distinguished by the absence of ovulation, there is no major producer of progesterone to counteract estrogen's effects. These women may exhibit symptoms of estrogen dominance, such as headaches, insomnia, bloating, fibrocystic breasts, acne, and more.

Furthermore, any defect in follicular development or corpus luteum function could cause a luteal phase defect. Luteal phase defect is marked by the failure to develop a fully mature secretory endometrium, preventing embryo implantation. This could lead to infertility or an early miscarriage.

Continue reading to learn more about progesterone's instrumental role in pregnancy, from how the hormone maintains a fetus to full-term to its effects in a new mother's body post-partum.

Bibliography

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