Bioidentical Progesterone Replacement Therapy Side Effects

Medically reviewed

Medically reviewed by Brenda G., MD | Written by SheCares Editorial Team | Updated: Jul 10, 2020

Bioidentical Progesterone Replacement Therapy Side Effects

For women whose hormonal condition is too risky for estrogen-only therapy, bioidentical progesterone may seem like the way to go. However, like any exogenous hormone treatment, it does not come without its risks. Continue reading to learn more about bioidentical progesterone side effects and drug interactions so that you can be that much closer to hormonal health.

More Common Bioidentical Progesterone Side Effects

The following is a list of some of the most common possible side effects of bioidentical progesterone:

More Common Bioidentical Progesterone Side Effects

While these symptoms don't typically require emergency medical treatment, you should inform your doctor to adjust doses.

Also, because it is common for bioidentical progesterone to cause feelings of sleepiness, women should take the dosage right before going to sleep. Bioidentical progesterone is not known to cause addiction nor decrease restorative sleep.

Less Common Bioidentical Progesterone Side Effects

On the other hand, the following is a list of less common yet more serious side effects that can evolve from taking bioidentical progesterone:

Less Common Bioidentical Progesterone Side Effects
  • Vaginal bleeding or spotting
  • Abnormal blood clotting leading to stroke, heart attack, vision loss, or pulmonary embolus
  • Severe and sudden onset headaches
  • Dizziness and faintness
  • Severe pains in chest or legs
  • Shortness of breath
  • Weakness and fatigue
  • Changes in vision or speech 
  • And more

In the event of suffering from any of these symptoms of too much bioidentical progesterone, seek medical assistance as soon as possible.

Potential Drug Interactions

Women on bioidentical progesterone therapy should be wary of any contraindications that might exist.

Some medications that have been found to interact with bioidentical progesterone include antifungal medications, like ketoconazole, as well as thyroid medications

To avoid complications, always tell your doctor about any other medicines that you may currently be on, including non-prescription medications, nutritional supplements, and herbal products.

Having outlined bioidentical progesterone side effects, continue on to the next section about another popular natural hormones option, bioidentical testosterone replacement therapy. Find out what you need to know to continue on the path to hormonal health and well-being today.

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