Bioidentical Estrogen Replacement Therapy Side Effects

By SheCares Editorial Team | rev. May 08, 2019

While bioidentical estrogen therapy may seem like a dream come true for some menopausal women who are battling hormonal imbalance symptoms disrupting their lives, the treatment does not come without its risks. Continue reading to learn more about bioidentical estrogen side effects and contraindications so that you can decide if it's best for you.

More Common Bioidentical Estrogen Side Effects

Side effects of bioidentical estrogen usually occur when a first dose is given as the body is not accustomed to the new level of hormones. Many will dissipate with time.

The following is a list of some of the most common side effects:

While these symptoms don't typically require emergency medical treatment, you should let your doctor know so that you can have your dose adjusted accordingly.

Less Common Bioidentical Estrogen Side Effects

On the other hand, the following is a list of less common yet more serious side effects that can evolve from taking bioidentical estrogen:

  • Chest, leg, arm, or groin pain
  • Nausea and vomiting
  • Severe and sudden onset migraines and headaches
  • Severe abdominal pain
  • Shortness of breath
  • Swelling or rapid weight gain
  • Vision or speech problems
  • And more

In the event of suffering from any of these symptoms as a result of taking bioidentical estrogen, seek medical assistance as soon as possible.

Potential Interactions

Women on bioidentical estrogen therapy should be aware of any contraindications that might exist. 

Some medications that have been scientifically proven to interact with bioidentical estrogen include antibiotics used to treat infections, like clarithromycin, as well as thyroid medications

To avoid issues, always tell a healthcare professional about any other medicines that you may be taking, including non-prescription medicines, nutritional supplements, and herbal products.

Having outlined bioidentical estrogen side effects, continue on to the next section concentrating on bioidentical progesterone replacement therapy. Find out what you need to know to take your hormonal health into your hands today.


  • The American College of Obstetricians and Gynecologists. (2012). Bioidentical Hormones. Obstetrics, 116(5), 1209-1210. doi: 10.1097/01.AOG.0000390402.85827.c0
  • Cleveland Clinic. (2014). Bioidentical Hormones. Retrieved April 29, 2019, from 
  • Mazer, N.A. (2004). Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women. Thyroid, 14 Suppl 1, S27-34. doi: 10.1089/105072504323024561
  • Vigesaa, K.A. et al. (2004). Efficacy and tolerability of compounded bioidentical hormone replacement therapy. International Journal of Pharmaceutical Compounding, 8(4), 313-319. Retrieved April 29, 2019, from

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